e ISSN- 2249-7668

Print ISSN- 2249-7676

ISSN

2249-7676

e ISSN

2249-7668

Publisher

pharmacology and toxicology

NEW BARIUM(II) INDOMETHACIN MEDICALCOMPLEX: SYNTHESIS, SPECTROSCOPIC AND BIOLOGICAL DISCUSSIONS
Author / Afflication
Adel S. Megahed

Department of Chemistry, Faculty of Science, Taif University, 888 Taif, Kingdom Saudi Arabia.
Keywords
Indomethacin ,Barium salt, ,Chelation ,Antimicrobial assessments ,
Abstract

Herein this paper dealing with the synthesis, spectroscopic and thermal discussions of Ba(II) indomethacin complex. New [Ba(Indo)2(H2O)4]complexwasstudied using elemental analysis, spectroscopic measurements (infrared, 1H-NMR and electronic). Elemental analysis of the chelates suggests the stoichiometry is 1:2 (metal-ligand). Infrared spectra of this complex agree with the coordination to the central metal atom through the carboxylate group as monodentate fashion. The TGA/DTG analyses of Ba(II) complex was performed. The Ba(II) complex has been screened in vitro against antimicrobial activities.The Ba(II) complex has great antimicrobial assessment than the free indomethacin drug

Volume / Issue / Year

5 , 2 , 2015

Starting Page No / Endling Page No

125 - 129