Department of Pharmacology and Toxicology, Unaizah College of Pharmacy, Qassim University, Al-Qassim 51452, Kingdom of Saudi Arabia.

Department of Pharmacology and Toxicology, Unaizah College of Pharmacy, Qassim University, Al-Qassim 51452, Kingdom of Saudi Arabia.
Nigella sativa ,thymoquinone ,Ischemic Cardiovascular Diseases ,Anti-oxidant ,

Ischemic Cardiovascular Diseases (ICVD) may be broadly classified into ischemic coronary heart disease, renal hypertension, ischemic cerebrovascular disease and peripheral vascular disease. The black seed, Nigella sativa (NS), a member of the family of ranunculaceae, is commonly used as a natural food additive. NS and its active constituents have been documented to exhibit antioxidant, hypotensive, calcium channel blockade and diuretic properties which may contribute to reduce blood pressure and exerting anti-ischemic effects via reduction in sympatheic overactivity and oxidative stress; suggesting a potential role of NS in the management of cardiovascular diseases as hypertension and ischemic coronary heart diseases and other non-cardiovascular ischemia. This study aiming for exploring the anti-ischemic properties of NS that protecting he heart and other vital organs against ischemia and decreasing incidence of myocardial infraction and ischemicreperfusion injuries on different body organs in experimental animal models and from clinical trials as found in ischemic heart patients received NS. The results provide a clear evidence that both the NS oil and its active ingredients, in particular thymoquinone (TQ), possessing reproducible anti-oxidant effects through enhancing the oxidant scavenger system against several ischemic insults and suggesting that the regular use of NS seed is recommended for prevention of ischemic cardiac and non-cardiovascular diseases

5 , 1 , 2015