Dept. of Research and Scientific studies, Prince Sultan Military college of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.

Dept. of Research and Scientific studies, Prince Sultan Military college of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.

Director, Prince Sultan Military College of Health Sciences, Dhahran-31932, Kingdom of Saudi Arabia.

Asst. Professor Dept of Pharmacology. Southern Institute of Medical Sciences, Guntur. Andhra Pradesh. India.
Dolichandrone falcate ,Brewer’s yeast ,Pyrexia ,Antipyretic activity ,

The aim of present study was to investigate the antipyretic effect of aqueous extract of stem bark of Dolichandrone falcata using Brewer’s yeast induced hyperpyrexia method in Wistar strain albino rats. This is being carried out with the intention of giving a scientific validity and justification of such herb indicated for the treatment of pyrexia. At a dose of 200mg/kg & 400mg/kg of aqueous extract of stem bark of Dolichandrone falcata were showed a significant (P<0.01) dose dependent antipyretic effect in yeast induced elevation of body temperature in experimental rats. The results showed that the extract contains some pharmacologically active principles and lend pharmacological credence to the ethnomedical use of the plant in the management of pyrexia and it shows significant antipyretic activity when compared with the standard drug.

4 , 3 , 2014