ISSN
2249-7676
e ISSN
2249-7668
Publisher
pharmacology and toxicology
ANALGESIC ACTIVITY OF ETHANOLIC ROOT EXTRACT OF RIVEA HYPOCRATERIFORMIS IN MICE
Author / Afflication
Kuruva Jyothirmai
St.John’s Collge of Pharmaceutical sciences, Yerrakota, Yemminganur, Kurnool, Andhra Pradesh, India
Alekhya M
St.John’s Collge of Pharmaceutical sciences, Yerrakota, Yemminganur, Kurnool, Andhra Pradesh, India
Besta Chandrasekhar
St.John’s Collge of Pharmaceutical sciences, Yerrakota, Yemminganur, Kurnool, Andhra Pradesh, India
Sareddy Harinatha Reddy
St.John’s Collge of Pharmaceutical sciences, Yerrakota, Yemminganur, Kurnool, Andhra Pradesh, India
Yeggoni Sreenivasulu
St.John’s Collge of Pharmaceutical sciences, Yerrakota, Yemminganur, Kurnool, Andhra Pradesh, India
Radha D
St.John’s Collge of Pharmaceutical sciences, Yerrakota, Yemminganur, Kurnool, Andhra Pradesh, India
Keywords
Acetic acid induced pain ,Ibuprofen ,Writhing movement ,
Abstract
The ethanolic extract of the roots of Rivea hypocrateriformis obtained by soxhlet extraction method was evaluated for analgesic action by Acetic Acid induced method. The ethanolic extract in doses of 200 and 400 mg/kg of Body weight showed 35.76 and 80.47% inhibition of writhing movements, respectively compared to that of standard Ibuprofen (100%). The ethanolic extract showed dose-dependent action in all the experimental models. The results were analyzed for statistical significance using one-way ANOVA followed by Dunnett’s test. A P value < 0.001 is considered significant.
Volume / Issue / Year
4 , 2 , 2014
Starting Page No / Endling Page No
138 - 141