Department of Pharmacology, Kurnool Medical College, Kurnool, Andhra Pradesh, India.

Department of Pharmacology, Kurnool Medical College, Kurnool, Andhra Pradesh, India.

Department of Pharmacology, Kurnool Medical College, Kurnool, Andhra Pradesh, India.

Department of Pharmacology, Kurnool Medical College, Kurnool, Andhra Pradesh, India.

Department of Pharmacology, Kurnool Medical College, Kurnool, Andhra Pradesh, India.
Vernonia cinerea ,Pylorus Ligation ,Ethanol Induced Gastric Ulcers ,

The aim of this study is to evaluate the anti-ulcer activity of methanol extract of leaves of Vernonia cinerea. The methanol extract of Vernonia cinerea (MEVC) was investigated for its anti-ulcer activity against pylorus ligation and ethanol induced gastric ulcers in rats. Ranitidine (50mg/kg,p.o.) and misoprostol (100ug/kg,p.o.) were used as standard drugs. A significant (p<0.01) anti-ulcer activity was observed in both the models. Both doses of Vernonia cinerea produced gastric anti-secretory effect in pylorus ligated rats and also showed gastric cytoprotective effect in ethanol induced gastric ulcers. It also showed significant (p<0.01) reduction in ulcer index in ethanol induced model with respect to control. This present study indicates that, Vernonia cinerea leaves extract have potential anti-ulcer activity in this tested models.

3 , 2 , 2013