Senior Lecturer, Department of Clinical Pharmacology, School of Health and Medical Sciences, The State University of Zanzibar, Tanzania

Senior Lecturer, Department of Surgery, The State University of Zanzibar, Tanzania

Professor, RVS Dental College and Hospital, Coimbatore, Tamil Nadu, India.

Senior Lecturer, Department of Pathology, The State University of Zanzibar. Tanzania
Heart failure, Uric Acid, Ejection Fraction. ,

Heart failure (HF), also known as congestive heart failure (CHF), is a complex clinical syndrome characterized by the inability of the to pump blood effectively due to structural or functional impairments. Heart failure can lead to clinical symptoms (dyspnea and fatigue) and signs (edema and rales) that lead to frequent hospitalizations, a poor quality of life, and a shortened life expectancy. Uric acid (UA), the final product of purine metabolism is elevated in hypoxic states. Cell death, tissue hypoxia, and impaired metabolism in HF increase xanthine oxidase activity, leading to an overproduction of UA. The aim of the study is to evaluate the correlation of uric acid levels with ejection fraction in heart failure patients. An observational study was conducted on patients with symptoms of Heart Failure in a tertiary care hospital. After screening the patients with inclusion and exclusion criteria and evaluating their clinical and 2D echocardiography findings 100 patients were included in the study. Complete heamogram, serum urea, serum creatinine, and blood glucose levels were evaluated. Levels of uric acid were compared with LVEF (Left Ventricular Ejection Fraction) to assess its prognostic significance and also compared the serum uric acid levels with functional NYHA class. Statistical analysis was done using SPSS software version 17.0. It is observed from the present study that most of the heart failure patients were between 40 – 70 years of age and incidence was equal in both male and female. There is a significant decrease in left ventricular ejection fraction in patients with high uric acid levels. This shows the strong inverse relationship between uric acid and LVEF. In conclusion, the analysis of correlation conclusively proves that when serum uric acid is more than 7 mg / dl, then either regional wall motion abnormality or global hypokinesia positive OR LVEF < 50 % in heart failure patients. The analysis also proves that serum uric acid levels are more in the severe functional disability patients (NYH III AND IV). This implies that Uric acid levels can be used as a marker for cardiac

15 , 2 , 2025