Assistant Professor, Department of General Medicine, Sree Balaji Medical College & Hospital, Chennai – 600044, Tamil Nadu, India
Hemolyticanemia, Sickle cell disease, Vitamin D deficiency, Bone mineral density, RANKL/OPG ratio ,

This study investigates the impact of hemolyticanemia on bone health, focusing on patients with sickle cell disease, thalassemia, and spherocytosis. A total of 90 patients were examined at Sri Lakshmi Narayana Institute of Medical Sciences & Hospital between January 2019 and May 2023. Biochemical markers, bone mineral density (BMD), and vitamin D levels were evaluated. Results revealed that 79.6% of patients had vitamin D deficiency, with 43.2% experiencing severe deficiency. Sickle cell disease patients exhibited the lowest 25-OH vitamin D levels and the highest RANKL/OPG ratios, indicating increased bone resorption. A significant correlation was observed between LDH levels and RANKL/OPG ratios, suggesting a link between hemolysis severity and bone turnover imbalance. Additionally, osteocalcin levels were significantly lower in hemolyticanemia patients than in controls. These findings highlight the need for routine bone health assessments and further research on preventive strategies for patients with chronic hemolytic conditions

9 , 2 , 2019