Assistant Professor, Department of Pharmacology, Bhaarath Medical College & Hospital, Selaiyur, Chennai, Tamil Nadu 600073, India
Alloxan, Pioglitazone, and Diabetes Treatmen ,

The research involves testing the drug pioglitazone, which is used to treat type 2 diabetes and works well. Researchers used three animal models to six mice each to study how pioglitazone affects diabetes from a pharmacological point of view. A first model was just a group that didn't get any treatment. The other 2 models were made of alloxan, and one was given medicine and the other was not. Animals were given Alloxan so that they would get diabetes. Alloxan is a -cytotoxin that is also known as mesoxalylurea, mesoxalylcarbamide, 2, 4, 5, 6-tetra-oxohexahye-4-pyrimide, & pyrimidine tetrone. It's been used a lot to give animals what is called "chemical diabetes" in real life.Compared to the vehicle, Pioglitazone lowered the blood sugar levels of diabetic mice made by alloxan (70 mg/kg)

11 , 2 , 2021