Pterolobium hexapetalum ,hepatoprotective ,CCl4 ,

Background: Pterolobium hexapetalum is one of the important medicinal plants belonging to Caesalpiniaceae., with significant herbal uses like anti diabetic, antiulcer, antiurolithic, antibacterial, anti fungal effects Pterolobium hexapetalum also possess high quantities of significant phytoconstituents like alkaloids, flavonoids, phenols, glycosides, tannins, quinines and steroids, which lead to use in many tropical countries. Due to its remarkable medicinal, nutritional and socio-economic value. This study was designed to clarify the protective effect of ethanolic extract of Pterolobium hexapetalum against carbon tetrachloride ccl4 induced hepatotoxicity in rats. Materials and Methods: Thirty white Albino male rats were used in this study and after acclimatization rats were subjected to different treatments blood and tissue samples were collected after day 10 post administration, biochemical, and histopathological examinations were utilized to investigate hepatoprotective activity of ethanolic extract of Pterolobium hexapetalum. Result: Pterolobium hexapetalum showed significant protection with the depletion of alalinine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatise (ALP) gamma glutanyl transpeptidase, in serum as it was raised due to ccl4 induction. Concentration of serum triglycerides, total cholesterol and low density lipo protein was were sceen to get reduced when treated with sylimarin as proven with administration of p.hexapetalum.there was amarkable increase in high density lipoprotein comparatively raise in total bilirubin and direct bilirubin was also reduced with administration of p.hexapetalum extract. Conclusion: From these results, it is suggested that Pterolobium hexapetalum possesses hepatoprotective properties

11 , 1 , 2021