Assistant Professor, Department of Biochemistry, Sri Lakshmi Narayana Institute of Medical Sciences, Kudapakkam Post, Puducherry, 605502, India.

Professor, Department of Pharmacology, Sri Lakshmi Narayana Institute of Medical Sciences, Kudapakkam Post, Puducherry, 605502, India.
Cirrhotic Cardiomyopathy ,Electrocardiography ,Creatinine Kinase MB ,Echocardiography ,cyclic Adenosine Monophosphate ,

Chronic Liver Disease is a procedure of liberal regeneration and destruction of the liver parenchyma leading to wide spectrum of changes like chronic hepatitis, cirrhosis or hepatocellular carcinoma. Cirrhosis is one of the most communal presentation of chronic liver diseases. Liver cirrhosis is related with simple hemodynamic changes that comprise hyperdynamic circulation with altered cardiac output, increased heart rate and abridged systemic vascular resistance. Cirrhotic cardiomyopathy is an entity reported in patient with radical cirrhosis. It is characterized by reduced contractile responsiveness to stress, altered diastolic relaxation and electrophysiological abnormalities (QT interval prolongation) all occurring in the absence of existing cardiac disease. At present there is evidence that, compromised liver function and portal hypertension with splanchnic vasodilatation lead to the development of the hyperdynamic changes4. Also other factors like increased sympathetic activity, increased blood flow and presence of arteriovenous communications can play significant role in pathogenesis. Many pathophysiological mechanisms like reduced beta-receptor action seem to be involved in the cardiac and autonomic dysfunction.

7 , 2 , 2017