Associate Professor,Department of Pharmacology, Gulbarga Institute of Medical Sciences, Kalaburagi, Karnataka, India

Tutor, Department of Pharmacology, Gulbarga Institute of Medical Sciences, Kalaburagi, Karnataka, India

Tutor, Department of Pharmacology, Gulbarga Institute of Medical Sciences, Kalaburagi, Karnataka, India
Hanging wire test ,Tardive dyskinesia test ,A.vera ,Haloperidol ,

In the recent past, for the management of diabetes, eczema, hypercholesterolemia is Aloe vera (Family: Liliaceae) used. The present allopathic medications used in Parkinson’s disease (PD) are exhibiting more side effects. Although A.vera is known for its antioxidative property, this property is explored for better neuroprotection. Methods: The mice of either sex were divided into 05 groups (n =12). Distilled water (orally), was given to 1st group mice, whereas, 2nd group were treated with haloperidol (1 mg/kg i.p.). A.vera (200, and 400 mg/kg/day, orally) respectively, along with haloperidol were given to 3rd, 4th groups respectively. Levodopa (30mg/kg, i.p,) along with haloperidol was given to Group 5. Hanging wire test, tardive dyskinesia test and whole board test were undertaken on the 7th and 15th day to assess the anti-Parkinson effect. One way ANOVA followed by post-hoc Tukey were used for statistical analysis. Results: Increase in hanging time significantly (p <0.001) and decreased in significantly (p <0.001) the Vacuous Chewing Movements (VCMS) was produced by Avira (200 and 400 mg/kg, p.o.) when compared to Haloperidol group. Significantly increase (p <0.001) in the number of dips in hole board test was observed by A.vera (200 and 400 mg/kg, p.o.) treated group when compared to Haloperidol group. Conclusions: In our study it is evident that A.vera exhibited beneficial effect in haloperidol treated Parkinson’s model mice

10 , 2 , 2020