Post graduate resident, Emergency Medicine Department, Kamineni Institute of Medical Sciences, Narketpally,Nalgonda, Telangana, India.

Head of the department, Emergency Medicine Department, Kamineni Institute of Medical Sciences, Narketpally, Nalgonda, Telangana, India

Post graduate resident, Emergency Medicine Department, Kamineni Institute of Medical Sciences, Narketpally,Nalgonda, Telangana, India.
Atropine ,promethazine ,organophosphorus poisoning ,antidote ,atropine induced psychosis ,

Among all pesticide poisoning deaths about 69% of people accounting to a number of 5 lakhs were of organophosphorus compound (OPC) poisoning in the last decade. This is due to OPC being a mere composition of all the pesticides available in the market. This is the most common threat found in developing countries. The drug of choice from decades that hasn’t changed is the use of anti-muscarinic agents for treating OPC poisoning. Its included atropine, oxime, benzodiazepine and others. In the recent years other drugs like anti-histamines have come into act for treating OPC poisoning. But, there are no evidences left for approaching the anti-histamine therapy due to scarcely studied outcomes on OPC poisoning. The serum sodium levels of group A after 1 hour and 3 hours of administration was reported to be 176 mEq/L and 154 mEq/L respectively. Serum potassium levels of group A were of 6.8 mEq/L and 6.5 mEq/L after 1 hour and 3 hours of administration of respective drug. Serum chlorine levels were assessed as 95 mEq/L and 94 mEq/L after 1 hour and 3 hours of administration respectively. In group B it was assessed the serum sodium levels were of 161 mEq/L and 157 mEq/L after 1 hour and 3 hours respectively. Serum potassium levels were assessed to be 6.2 mEq/L and 6.0 mEq/L respectively after 1 hour and 3 hours of administration of drug. Serum chlorine levels were assessed to be 110 mEq/L and 98 mEq/L after 1 hour and 3 hours of administration of drug. The sodium and potassium concentrations in the blood or urine of the subjects used under these experimental conditions showed little change of importance after atropine administration. We conclude from the study that promethazine is preferable to atropine due to its lesser impact on CVS, CNS and serum electrolytes.

9 , 2 , 2019