Department of Pharmacology, TVES HLMC College of Pharmacy Faizpur 425503, India.

Department of Pharmacology, TVES HLMC College of Pharmacy Faizpur 425503, India.
Antidepressant ,Clitoria ternatea ,

Depressive disorder is a prevalent psychiatric disorder, which affects 21% of the world population. The presently using drugs can impose a variety of side-effects including cardiac toxicity, sexual dysfunction, body weight gain, and sleep disorder. During the last decade, there is a growing interest in the therapeutic effects of natural products on mental disorders. In this study, we investigated the antidepressant effects of Methanolic extract of Clitoria ternatea (MECT) roots, using rat as an animal model at the doses of 250 mg/kg and 500 mg/kg body weight. The antidepressant activity was investigated by utilizing Tail suspension test (TST). The results showed that MECT (500 mg/kg) showed significant (p<0.001) antidepressant activity when compared with control. MECT (500 mg/kg) has not showed statistically significant reduction in locomotor score. Preliminary phytochemical screening of the extract revealed the presence of phenolic compounds, alkaloids, tannins, glycosides and flavonoids. These results demonstrated that the MECT exhibited good potential against depression.

9 , 2 , 2019