Assistant Professor, S.V. Medical College, Tirupati, Andhra Pradesh, India.
Lidocaine ,Amiodarone ,Ventricular Tachycardia ,Local Anesthetics ,

Amiodarone is considered as one of the ideal medicine for incessant ventricular tachycardia, due to its properties like amidoarone is known to lack cardiotoxic properties being an amino-aqueous component observed during initial preclinical studies. It is formulated in a combination of amiodarone/Tween 80/ benzyl alcohol. Amiodarone was proven to be less toxic in comparison with cordarone when administered Intravenously in rats with a 50% lethal dose of 50 mg/kg for amiodarone and 35mg/kg for cordarone. In a number of uncontrolled and small studies it was reported that IV administration of amiodarone is effective in terminating ventricular tachycardia (VT). Lidocaine being an local anesthetic is also considered as one of the best drug for cardiac arrhythmias for cardio ventricular tachycardia. Various other parameters like VT termination was recorded to be 17.85% in amino-aqueous group and 81.81% in lidicaine group, 1-hour survival was 7.14% in amiodarone and 54.54% in lidocaine. 24-hour survival was recorded to be 7.14% in amiodarone and 54.54% in lidocaine group. Crossed over was reportedly 39.28% in amiodarone and 54.54% in lidocaine as represented in table 2 and table 3. The various side effects by administration of amiodarone and lidocaine was recorded which included asystole, bradycardia, hypotension, progressive heart failure, seizures, slurred speech and hallucination have been recorded which was observed to be more with lidocaine in comparison with amiodarone

6 , 2 , 2016