Syed Wasif
Hypertension, Atenolol, Amlodipine. ,

Background: Hypertension is the most common cardiovascular disease. The prevalence of hypertension increases with advancing age. The beta receptor antagonists provide effective therapy for all grades of hypertension. Compared with other classes of antihypertensive agents, there is a greater frequency of achieving blood pressure control with Ca2+ channel blockers as monotherapy. Because of paucity of published reports in the Indian literature regarding the pattern of use, efficacy, safety, tolerability of comparison of therapy of amlodipine and combination of amlodipine and atenolol, the present study was taken up. Objectives: To study the comparison of efficacy, safety and tolerability of amlodipine and combination of amlodipine and atenolol in achieving blood pressure control. Materials and Methods:100 properly selected subjects with hypertension were included for the present study. The medication were used empirically as monotherapy or combination, OD or BID in a continuation manner. Blood pressure was measured at the baseline and daily afterwards for one month. The data collected was analyzed statistically using descriptive statistics. Tolerability and patient compliance for the prescribed medications were also assessed during the follow up visits. Results: Blood pressure is maintained at the baseline level in both the study subjects. A few subjects with amlodipine shows more blood pressure variability compare to combination. Minor side effects were noted in both the subjects with nearly same frequency. The patient compliance for the prescribed medications was excellent. Interpretation and Conclusion: Hypertension can be effectively treated by combination of amlodipine and atenolol than amlodipine alone.

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