Department of Pharmacy, Vishwabharathi College of Pharmaceutical sciences, Perecherla, Guntur (dt), Andhra Pradesh, India.

Department of Pharmacy, Annamalai University, Chidambaram, Tamilnadu, India
Chalcone based pyrazoline derivative ,Chromosomal aberration study ,Mutagenicity ,Anti mutagenicity ,Salmonella typhimuriu ,

To study the toxicological studies of chalcone based pyrazoline compounds in which mutagenicity induced by 4- nitroquinolene-1-oxide in Salmonella typhimurium, and it was opposed by pyrazoline derivative is i.e.compound Py4.i.e. [3 (4-(N-acetyl-5-(methoxyphenyl)-4, 5 dihydro-1H-pyrazol-3-yl) phenyl quinazoline-4(3H) one] at different concentrations but its antimutagenicity and chromosomal aberration actions are observed at 5 mg/plate.Chalcone based pyrazoline derivative showed a significant protective effect against mutagenicity induced by mutagen in S. typhimurium TA98 strain with or without metabolic activation. The emphasis of this work is to investigate the possible mutagenic, anti-mutagenic and chromosomal aberration properties of Compound 3 (4-(N-acetyl-5-(methoxyphenyl)-4, 5 dihydro-1H-pyrazol-3-yl) phenyl quinazoline- 4(3H) one with Ames assay and Chromosomal aberration. Similarly, invitro chromosomal aberration assay did not reveal any significant alterations up to 5 mg/culture as compared to the negative control both in the presence and absence of the metabolic activation (S9 mix). The results of these studies indicate that compound is non-mutagenic in Ames test, exhibit protection against the mutagenicity induced by 4-nitroquinolene-1-oxide, sodium azide and 2- aminoflourene in TA98 and TA100 strain system.

6 , 1 , 2016