Department of Biochemistry, Sera Care Lab and Research Centre, Jodhpur, India.

Department of Biochemistry, Sera Care Lab and Research Centre, Jodhpur, India.

Department of Zoology, Jai Narain Vyas University, Jodhpur-342005, India

Department of Zoology, Jai Narain Vyas University, Jodhpur-342005, India
Antiplatelet ,Hyperlipidemia ,Atherosclerosis ,Policosanol ,Cholesterol ,

Policosanol has been reported to decrease total cholesterol and low density lipoprotein (LDL) cholesterol. The comparative hematological study was conducted in policosanol treated animals to evaluate its safety potential in white male albino rabbits. Four groups of 6 male albino rabbits each were used for study. To Intact control group no drug was given, to hyperlipdemic control group atherogenic diet with cholesterol powder (500 mg/kg body weight) mixed in 5ml coconut oil was given. To group 3 & 4 policosanol and statin was given as drug by oral administration; the drug treatment was carried out for complete 60 days. Animals were sacrificed by prolonged ether anesthesia after the 24 hours of last dose of drug, blood and serum samples were collected for the hematological and biochemical assays. The platelet count showed reduction from its normal range showing anti platelet activity while other hematological parameters like erythrocyte count, leucocyte count, hemoglobin count etc. were found to be in normal range. Other parameters like urea, creatinine etc, remain normal owing to nontoxic nature of drug

5 , 1 , 2015