Vaageswari College of Pharmacy, Karimnager, Andhra Pradesh, India.

Department of Pharmaceutical Chemistry, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, India.

Department of Pharmaceutical Analysis, Kakatiya Institute of Pharmaceutical sciences, Penbarthy, Warangal, Andhra Pradesh, India.

Vaagdevi College of Pharmacy, Medicinal Chemistry Research Division, Hanamkonda, Warangal, Andhra Pradesh, India

Vaagdevi College of Pharmacy, Medicinal Chemistry Research Division, Hanamkonda, Warangal, Andhra Pradesh, India
Antiepileptic activity ,Traditional Medicine ,Barringtonia acutangula (L.) ,biogenic amines ,

The leaves of Barringtonia acutangula (L.) are used traditional Indian medicine to treat epilepsy. Previous studies have demonstrated that extracts of these plants was subjected to acute toxicity and then screened for antiepileptic activity on Pentylenetetrazole (PTZ) induced seizure model in albino wistar rats. The purpose of the present study is to investigate the effect of ethanol extract of Barringtonia acutangula (L.) (EBA) on biogenic amines concentrations in rat brain after induction of seizures by PTZ. Our aim of study was relationship between seizure activities and altered the monoamines such as noradrenaline (NA), dopamine (DA), serotonin (5-HT) in forebrain of rats in PTZ seizure model. In PTZ model, EBA showed significantly increased the monoamines in forebrain of rats. Thus, this study suggests that ethanol extract of Barringtonia acutangula (L.) increased the monoamines on rat brain, which may be decreased the susceptibility to PTZ induced seizure in rats.

4 , 2 , 2014