e ISSN- 2249-7668

Print ISSN- 2249-7676

ISSN

2249-7676

e ISSN

2249-7668

Publisher

pharmacology and toxicology

ANTI-ULCEROGENIC ACTIVITY OF METHANOL EXTRACT OF VERNONIA CINEREA IN ALBINO WISTAR RATS
Author / Afflication
Swarupa Rani P

Department of Pharmacology, Kurnool Medical College, Kurnool, Andhra Pradesh, India.
Vijaya Bhaskar Reddy Y

Department of Pharmacology, Kurnool Medical College, Kurnool, Andhra Pradesh, India.
Sharon Sonia S

Department of Pharmacology, Kurnool Medical College, Kurnool, Andhra Pradesh, India.
Rajesh P

Department of Pharmacology, Kurnool Medical College, Kurnool, Andhra Pradesh, India.
Swarnalatha K

Department of Pharmacology, Kurnool Medical College, Kurnool, Andhra Pradesh, India.
Keywords
Vernonia cinerea ,Pylorus Ligation ,Ethanol Induced Gastric Ulcers ,
Abstract

The aim of this study is to evaluate the anti-ulcer activity of methanol extract of leaves of Vernonia cinerea. The methanol extract of Vernonia cinerea (MEVC) was investigated for its anti-ulcer activity against pylorus ligation and ethanol induced gastric ulcers in rats. Ranitidine (50mg/kg,p.o.) and misoprostol (100ug/kg,p.o.) were used as standard drugs. A significant (p<0.01) anti-ulcer activity was observed in both the models. Both doses of Vernonia cinerea produced gastric anti-secretory effect in pylorus ligated rats and also showed gastric cytoprotective effect in ethanol induced gastric ulcers. It also showed significant (p<0.01) reduction in ulcer index in ethanol induced model with respect to control. This present study indicates that, Vernonia cinerea leaves extract have potential anti-ulcer activity in this tested models.

Volume / Issue / Year

3 , 2 , 2013

Starting Page No / Endling Page No

62 - 66