Department of Pharmaceutics, Mahathi College of Pharmacy, CTM X Road, Chittoor (Dt), Madanapalle, Andhra Pradesh, 517 319.

Department of Pharmacognosy, Santhiram College of Pharmacy, Srinivas Nagar, Kurnool (Dt), Nandyal, Andhra Pradesh, 518 501.

Department of Pharmacognosy, Anurag Pharmacy College, Ananthagiri (V), Kodad (M), Nalgonda (Dt), Andhra Pradesh, 508 206.
Anti-epileptic activity ,Malachra capitata L ,Maximal Electroshock (MES) ,Pentylenetetrazole (PTZ) ,

The present study is an investigation of anti-epileptic activity of Malachra capitata L. (Family- Malvaceae) is a wellknown plant which is being used in Indian traditional medicines for treating epilepsy and inflammation. The aqueous extract of Malachra capitata L. (AMC) was subjected to acute toxicity and then screened for anticonvulsant activity on Maximal Electroshock (MES) and Pentylenetetrazole (PTZ) induced seizures models in albino wistar rats. Acute toxicity of extract was non toxic up to the recommended dose 2000 mg/kg. p.o. Animals were treated with AMC at doses of 250 and 500 mg/kg body weight. Study results showed, the mean duration of extensor phase of treated groups reduced significant level than compared to control group. In Pentylenetetrazol induced seizure model, onset of myoclonic spasm and clonic convulsion was delayed in the AMC treated groups. AMC showed anti-epileptic activity against MES and PTZ animal models. However, further studies still needed to be carried on exposure of the extract to humans.

2 , 2 , 2012