ISSN
2249-7676
e ISSN
2249-7668
Publisher
pharmacology and toxicology
Don Bosco College of Pharmacy, Pulladigunta, Kornepadu (V), Vatticherukuru (M), Guntur, Andhra Pradesh - 522017.
Don Bosco College of Pharmacy, Pulladigunta, Kornepadu (V), Vatticherukuru (M), Guntur, Andhra Pradesh - 522017.
Don Bosco College of Pharmacy, Pulladigunta, Kornepadu (V), Vatticherukuru (M), Guntur, Andhra Pradesh - 522017.
Don Bosco College of Pharmacy, Pulladigunta, Kornepadu (V), Vatticherukuru (M), Guntur, Andhra Pradesh - 522017.
Don Bosco College of Pharmacy, Pulladigunta, Kornepadu (V), Vatticherukuru (M), Guntur, Andhra Pradesh - 522017.
Primary brain tumors have a significant infiltrative capacity as their reappearance after resection usually occurs within 2 cm of the tumor margin. Local delivery method such as Convection-Enhanced Delivery (CED) has been introduced to avoid this recurrence by delivering active molecules via positive-pressure. The technical approach of CED with regard to catheter design and brain characteristics; secondly, we will describe the ‘ideal’ nanocarrier in terms of size, surface properties, and interaction with the extracellular matrix for optimal diffusion in the brain parenchyma. We also discuss preclinical and clinical applications of this new method. The role of PET in the visualization of the biological characteristics of the tumours: proliferation (FLT-PET), hypoxia (FMISO-PET) and angiogenesis/ peptide expression (RGD-PET) should be investigated in future studies.
2 , 2 , 2012
60 - 66