e ISSN- 2249-7668

Print ISSN- 2249-7676

ISSN

2249-7676

e ISSN

2249-7668

Publisher

pharmacology and toxicology

BRAIN TUMOUR - METHODS OF TREATMENT
Author / Afflication
Jayalakshmi K

Don Bosco College of Pharmacy, Pulladigunta, Kornepadu (V), Vatticherukuru (M), Guntur, Andhra Pradesh - 522017.
Surya Prabha M

Don Bosco College of Pharmacy, Pulladigunta, Kornepadu (V), Vatticherukuru (M), Guntur, Andhra Pradesh - 522017.
Baburao CH

Don Bosco College of Pharmacy, Pulladigunta, Kornepadu (V), Vatticherukuru (M), Guntur, Andhra Pradesh - 522017.
Shobana G

Don Bosco College of Pharmacy, Pulladigunta, Kornepadu (V), Vatticherukuru (M), Guntur, Andhra Pradesh - 522017.
Rathna Kumari K

Don Bosco College of Pharmacy, Pulladigunta, Kornepadu (V), Vatticherukuru (M), Guntur, Andhra Pradesh - 522017.
Keywords
Convection-enhanced delivery ,Nanocarrier ,Anticancer treatment ,Glioblastoma ,Viral vectors ,Suicide genes ,Braintumors ,Radiation treatment planning ,
Abstract

Primary brain tumors have a significant infiltrative capacity as their reappearance after resection usually occurs within 2 cm of the tumor margin. Local delivery method such as Convection-Enhanced Delivery (CED) has been introduced to avoid this recurrence by delivering active molecules via positive-pressure. The technical approach of CED with regard to catheter design and brain characteristics; secondly, we will describe the ‘ideal’ nanocarrier in terms of size, surface properties, and interaction with the extracellular matrix for optimal diffusion in the brain parenchyma. We also discuss preclinical and clinical applications of this new method. The role of PET in the visualization of the biological characteristics of the tumours: proliferation (FLT-PET), hypoxia (FMISO-PET) and angiogenesis/ peptide expression (RGD-PET) should be investigated in future studies.

Volume / Issue / Year

2 , 2 , 2012

Starting Page No / Endling Page No

60 - 66